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论文编号:HG142 论文字数:9056,页数:25
摘 要：首先以D-核糖为起始原料，2,2-二甲氧基丙烷作为保护基原料，得到甲基-2,3-O-异亚丙基-β-D-呋喃核糖苷，然后用甲苯黄酰氯保护得到甲基-2,3-O-异亚丙基-5-o-甲苯磺酰基-β-D-呋喃核糖苷，继续用硼氢化钠还原得到甲基-2,3-O-异亚丙基-5-脱氧-β-D-呋喃核糖苷。经过对原有合成路线的优化改进，此反应操作方便简单，重复性好，反应时间短，反应平和，产物易纯化，在工业上有较大的应用价值。
关键词： D-核糖;甲基化;乙酰化;呋喃核糖苷
Abstract: Methyl-2,3-O-isopropylidene-β-D-ribofuranoside was prepared from D-ribose protected by 2,2-dimethoxypropane. Methyl-2,3-O-isopropylidene-5-o-trifluoromethanesulfonyl -β-D-ribofuranoside glucoside was synthesized from methyl-2,3-o-isopropylidene-β-D- ribofuranoside and TSCl. Then Methyl-2,3-o-isopropylidene-5-o-trifluoromethanesulfonyl-β- D-ribofuranoside glucoside was reduced by NaBH4 to get methyl -2,3-O- isopropylidene-5- deaeration - beta -D- ribofuranose glucoside. Through the optimization and improvement of original process , this reaction is simple, duplicates well, reaction time is short, preceeds smothly, and the product is easy to purify, has the wided application in the industry.
Keywords：D- ribose; methyl; acetylize; furan ribofuranose
目 录
中文摘要....................................................................I
英文摘要...................................................................II
目录......................................................................III
1. 绪论....................................................................1
1.1 选题的背景与意义....................................................1
1.2 呋喃及其衍生物的应用................................................1
1.3 文献合成方法综述....................................................2
1.4 研究的基本内容与拟解决的主要问题....................................3
1.5 合成路线选择........................................................4
1.6 本章小结............................................................4
2. 实验部分................................................................5
2.1 实验试剂............................................................5
2.2 实验原料的物性......................................................5
2.3 实验仪器............................................................7
2.4分析仪器 ...........................................................7
2.5 实验装置图..........................................................9
2.6实验步骤............................................................11
2.7 本章小结...........................................................13
3. 结果与讨论............................................................14
3.1实验结果............................................................14
3.2实验讨论...........................................................17
3.3 本章小结..........................................................18
4. 结论 .................................................................19
致谢.......................................................................20
参考文献...................................................................21
