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说明:
【摘要】 心肌保护近年来的发展多注重基础研究紧密联系临床,积极转化为临床实践,心肌保护液的添加成分、减轻炎症反应的策略、缺血预调在临床方面的应用都是学者们高度关注的重要部分,能够转化到临床,成为有效的心肌保护措施。
【关键词】 心肌保护,缺血预调,炎症反应
【Abstract】 Recent years,the development of myocardial protection emphasized in what can provide tight junction between fundamental research and clinical practice.scholars pay highly attention to the elements added to cardioplegia,strategy to reduce inflammatory reaction,the application of ischemic preconditioning in clinical practice,which can be translate into clinical and become efficiently strategy for myocardial protection.
【Key words】 myocardial protection;ischemic preconditioning;inflammatory reaction
尽管心肌保护已经发展了多年,但在急性心梗的治疗及心脏手术的临床应用当中,心肌保护的方法和效果有待于进一步开拓。近年来在心肌保护液的添加成分、控制全身炎症反应、缺血预调等方面有些新的观点及进展,本文就此综述如下。
目录:
1 心肌保护液的进展
2 控制全身炎症反应综合征(SIRS)的策略
3 Na+-H+交换抑制剂
4 心肌缺血预调(ischemic preconditioning,IP)
参考文献:
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作者点评:
IP结语 IP调动内源性保护机制,通过各种信号转导途径,进而触发信号分子事件的连锁反应,激活转录因子,介导保护性蛋白的基因表达从而降低细胞的氧化应激和炎症反应,提高心肌细胞自身对缺血、缺氧的耐受能力,为心肌保护提供了一个新的途径。随着对IP机制研究不断地深入及临床实施IP方法的不断改进,IP在心肌保护方面的效应将会更加明显。