多中心不对称催化配体的合成

论文编号:ZY072    论文字数:11578,页数:27

摘要：手性氨基醇是一类具有很大发展潜力的用于催化不对称合成反应的配体或催化剂。本论文在查阅相关资料的基础上综述了不对称催化反应的研究新进程，以天然手性氨基酸为原料，合成了一个新的多官能团手性氨基醇配体，并用红外，熔点等测试方法确定了该化合物的结构。
 我们分别使用了以（1R，2S）-(-)-2氨基-1,2-二苯基乙醇和（1R，2S）-(+)-2氨基-1,2-二苯基乙醇为手性源，乙腈和DMSO为溶剂，K2CO3为缚酸剂，少量KI为催化剂，与1,3-二溴甲基苯合成含二催化中心配体；与1,3,5-三溴甲基苯合成含三催化中心配体。经硅胶柱色谱纯化得到白色晶体。产物经红外确认，其他物理常数也较理想。
关键词：手性氨基醇；配体；合成；提纯

Abstract: Chiral amino alcohol is a kind of the ligand or catalyst with great potential for the development of catalytic asymmetric synthesis. In this paper the inspection on the basis of relevant information summarizes the asymmetric catalytic reduction of new progress. It is to hand a new multi-functional hands of the amino alcohol ligand synthesized from natural amino acids,and used Infrared to determine the structure of the compound..
   We use the (1R,2S)-(-) or (1S,2R)-(+)-2-amino-1,2-diphenyl ethanol as chiral source, Acetonitrile as solvent , K2CO3 for lashing acid , a small amount of KI as a catalyst , and 1,3-two benzyl bromide to synthesize two catalytic centre ligand and 1,3,5-three benzyl bromide to synthesize three catalytic centre ligand by silica gel column chromatography in the white color crystals , and the melting point of products for polarimetry . products by IR to confirm its structure in which the pair of enantionmers . the degree of physical constants are very good verification .

Key words : chiral amino alcohol ; ligand ; synthesis ; purification

              
目  录
中文摘要 I
英文摘要 II
目录 III
1. 绪论 1
 1.1 引言 1
 1.2手性化合物 2
 1.3获得手性化合物的方法 3
 1.4手性化合物的合成 3
 1.5手性氨基醇的合成 5
 1.6本实验研究的意义 5
 1.7展望 6
2. 实验部分 7
 2.1实验仪器 7
 2.2实验试剂 7
 2.3合成路线的设计 8
 2.4实验步骤 9
3. 结果与讨论 11
 3.1实验结果 11
 3.2讨论 17
4．总结与展望 18
致谢 19
参考文献 20
附录 22