高磷血症新药司维拉姆的合成及其功效的研究

论文编号:HG078  论文字数:10877,页数:22

摘 要：本论文研究治疗高磷血症的药物。盐酸司维拉姆是一种阳离子多聚体，主要成分是盐酸多聚丙烯酰胺，可与磷结合。生理pH下其氨基几乎完全质子化，通过离子交换结合磷，在胃肠道内水合膨胀成数倍于原体积的凝胶，且不被肠道吸收。临床试验表明盐酸司维拉姆能有效地降低血磷水平，其效果可与含钙磷结合剂媲美。盐酸司维拉姆不会引起高钙血症，可显著减少心血管病变的发病率。此外，应用盐酸司维拉姆降低血磷时，可以使用钙三醇控制继发性甲状旁腺功能亢进。目前盐酸司维拉姆被认为是一种较理想的磷结合剂。但有报道盐酸司维拉姆有轻度降低血液中碳酸氢盐的水平、减少脂溶性维生素A、D、E、K的吸收等副作用，使其临床应用受到一定限制。盐酸司维拉姆长期使用的安全性仍有待进一步验证。

 关键词：高磷血症；磷结合剂；环氧氯丙烷

The Pharmaceutical Research Division Villam
 
Abstract: This article is about the drug treatment of hyperphosphataemia.Division Villam hydrochloride is a cationic polyme ,Major components hydrochloride polyacrylamide, can be combined with the phosphorus.Physiological pH, the protonated amino almost entirely through the combination of ion exchange of phosphorus in the gastrointestinal tract hydration expansion into several times the original volume of the gel, And not by intestinal absorption. Clinical trials show that the Secretary Villam hydrochloride can effectively reduce serum phosphorus levels, the effect can be comparable with the phosphate binder. Secretary Villam hydrochloride does not cause hypercalcemia, can significantly reduce the incidence of cardiovascular disease. In addition, the application of hydrochloric acid Division Villam reduce phosphorus, you can control the use of calcitriol secondary hyperparathyroidism. Currently the Division Villam hydrochloride is considered an ideal phosphate binder. But it was reported slightly lower hydrochloride Division Villam blood bicarbonate levels, reduce the fat-soluble vitamins A, D, E, K absorption and other side effects, its clinical application is limited. Long-term use hydrochloride Division Villam security is yet to be verified.

Keywords：Hyperphosphataemia ; Phosphate binder; Epichlorohydrin

目  录
中文摘要 I
英文摘要 II
目录 III
1. 绪论 1
 1.1  背景 1
 1.1.1 高血磷症概况 2
 1.1.2 高磷血症对策 3
 1.1.3 相关知识 5
 1.2 司维拉姆的合成 8 
2. 实验部分 11
 2.1 实验仪器和试剂 11
 2.2实验步骤 12
3. 结果与讨论 13
 3.1   丙烯胺盐酸部分 13
 3.2   聚丙烯胺的交联部分 14
 3.3  磷酸结合度的分析 14
4．总结与展望 16
致谢 17
参考文献 18