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论文编号:HG247 论文字数:15133,页数:27
摘要
21世纪纳米技术在生物学和制剂方面应用被认为是最有吸引力的研究领域，它不仅阐明了传统药物溶解度低，高毒性和稳定性差对其应用有较强的限制，而且还在控制剂量的同时提高了他们的治疗效率。但同时，纳米药物也给我们带来很多问题，因为它能够改变药代动力，这就是所谓的纳米毒性。因此，使纳米药物得到甚为广泛的应用仍是一个漫长的道路。一些最前沿的问题是纳米药物的分散、分解、释放、疗效以及对人体生理功能和新陈代谢的影响。本实验利用磷脂做乳化剂，豆油和水，通过紫外分光光度计法检测，最终确定了其最佳处方是豆油3.5ml、甘油3.5ml、磷脂750mg、加水至15ml；并为已知处方的聚山梨酯-80制备纳米乳剂的方法确定了最佳的生产工艺为超声-恒温搅拌法。
关键字：纳米乳剂 制备 评价
Preparation and Evaluation Of Nanoemulsion
Abstract:
The 21st century nanotechnology applies in the biology and the preparation aspect was considered that is the most attractive research area, it had not only expounded the traditional medicine solubility is low, toxic and the stability have the strong limit badly to its application, moreover also raised their treatment efficiency during control dosage''''s. But simultaneously, a nanometer medicine also brings many questions to us, because it can change a medicine generation of power, this is the so-called nanometer toxicity. Therefore, enabled a nanometer medicine to obtain is really the widespread application was still a long path. Some most front''''s question is the nanometer medicine dispersion, the decomposition, the release, the curative effect as well as to the human body physiology function and metabolism influence. This experiment makes the emulsifier using the phosphatide, the soybean oil and the water, through the ultraviolet spectrophotometer examination, finally we had determined its best prescription is soybean oil 3.5ml, glycerine 3.5ml, phospho-lipin 750mg, the watering to 15ml; And gathered the tween- 80 preparation nanometer emulsion method for the known prescription to determine the best technique of production is the supersonic - constant temperature puddle process.
Key words : nanoemulsion preparation evaluate
目录
摘要 1
Preparation and Evaluation Of Nanoemulsion 2
1.文献综述 4
1.1纳米乳剂概述 4
1.2纳米乳剂的特点 4
1.3微乳形成原理 5
1.3.1表面活性剂的选择 5
1.3.2 助乳化剂的选择 6
1.3.3油相的选择 6
1.4常用的乳化剂和助乳化剂 8
1.4.1天然乳化剂 8
1.4.2合成乳化剂 8
1.4.3混合乳化剂 10
1.4.4助乳化剂 10
1.5微乳的评价方法 11
1.5.1物理稳定性评价 11
1.5.2化学测定法 15
2.实验部分 16
2.1．试验材料 16
2.2仪器 16
2.3纳米乳剂的制备 16
2.3.1用聚山梨酯-80制备纳米乳剂 16
2.3.3利用磷脂制备纳米乳剂 17
2.3.4纳米乳剂的评价方法 18
3结果与讨论 20
3.1利用聚山梨酯-80超声法制备纳米乳剂 20
3.2以磷脂做乳化剂制备纳米乳剂 22
4结论 25
5致谢 26
6参考文献 27
