羧甲基壳聚糖水凝胶在应用药物管制

论文编号:HG308   论文字数:24658,页数:37

摘要
 以戊二醛为交联剂制备了一系列羧甲基壳聚糖水凝胶。重点研究水凝胶的溶胀率、PH敏感性和各因素对羧甲基壳聚糖水凝胶溶胀性能的影响，如羧甲基壳聚糖脱乙酰度对水凝胶溶胀率的影响、交联剂的浓度对水凝胶溶胀率的影响，并以水杨酸为模型药物进行了释药性能研究。实验结果表明羧甲基壳聚糖的脱乙酰度、交联剂用量对水凝胶溶胀率的影响较大。PH=3.0时,水凝胶收缩,而PH=1.0 ,5.0 ,7.4 ,9.0时 ,水凝胶溶胀,且在碱性条件下水凝胶的溶胀率远大于酸性条件下的溶胀率。包埋在此水凝胶中的水杨酸释放随载药介质的PH值和水凝胶半径大小的变化而显著不同,PH=1.0条件下载药的水凝胶的释药率大于PH=7.4 ,12.0条件下的释药率 ,且水凝胶的半径越大 ,释药速度和释药率也越大。

关键词：羧甲基壳聚糖水凝胶 , 溶胀率 , 水杨酸 , 控制释放

Title:Carboxymethyl chitosan hydrogels in the application of drug control
Abstract：
Hydrogels based on carboxymethyl chitosan(CMCTS) were synthesized by using glutaraldehyde as cross-link agenl. Focus on the swelling rate, pH-sensitivity and various factors on swelling properties of carboxymethyl chitosan hydrogel,such as the effects of the degree of deacetylation of CMCTS on the swelling behaviors of hydrogels, the effects of crosslinker concentration on the swelling behaviors of hydrogels ,and salicylic acid as a model for the release of drug have been studied.The results show that the two factors related above regulate their swelling behavior.At PH=3.0,the hydmgel shfinked most while swelled at PH=1.0,5.0,7.4,9.0.In general the swelling ratio(SR) of this hydrogel in alkaline solution is much larger than that in acidic solution.The release behavior of salicylic acid(SA) entrapped in the hydrogels was of distinctly difference with the changes of PH value of loading medium and the semidiameter of the hydrogels.The release of salicylic acid in CMCT hydmgel in the mediumof PH=1.0 was much quicker in PH=7.4,12.0,and the release speed and release ratioincrease with the particalsize.
   

Keywords:carboxymethyl chitosan hydrogels,swelling rate,salicylic acid,
controlled release

 
 
 目           录
1.文献综述 1
1.1引言 1
1.2壳聚糖 1
1.3甲壳素/壳聚糖及其衍生物的制备研究 2
1.3.1甲壳素的制备 3
1.3.2壳聚糖的制备 3
1.3.3壳聚糖衍生物的制备 4
1.4.壳聚糖在生物医药中的应用 5
1.5羧甲基壳聚糖的功能性质与结构关系 8
1.5.1取代基团特性 8
1.5.2取代位置 8
1.5.3取代程度（Degree of substitute,DS） 8
1.5.4取代分布 9
1.5.5聚合度及其分布 9
1.6羧甲基壳聚糖的制备 9
l.6.1 N，O-羧甲基壳聚糖的制备 9
1.6.2羧甲基壳聚糖的水溶液性质 10
1.6.3羧甲基壳聚糖的应用 11
1.7水凝胶 14
1.7.1水凝胶的分类 15
1.7.2高分子水凝胶的制备 15
1.7.3水凝胶的应用 16
1.8本课题的意义和创新点： 18
1.8.1 选题的意义 18
1.8.2 创新点 18
2.实验部分 20
2.1试剂和仪器 20
2.2羧甲基壳聚糖的制备 20
2.3羧甲基壳聚糖水凝胶( CMCTH)的合成 21
2.4水凝胶溶胀率的测定 22
2.5水凝胶结构表征 22
2.6羧甲基壳聚糖脱乙酰度对水凝胶溶胀率的影响 23
2.7交联剂的浓度对羧甲基壳聚糖水凝胶溶胀率的影响 23
2.8水杨酸的吸附与释放 23
3. 结果与讨论 24
3.1羧甲基壳聚糖水凝胶溶胀动力学 24
3.2羧甲基壳聚糖水凝胶的PH敏感性 24
3.3羧甲基壳聚糖脱乙酰度对水凝胶溶胀率的影响 25
3.4交联剂的浓度对羧甲基壳聚糖水凝胶溶胀率的影响 26
3.5水杨酸在该水凝胶中的吸附和释放研究 27
3.5.1不同PH下水杨酸的控制释放 27
3.5.2水凝胶的半径大小对于该控制释放体系的影响 28
3.6红外表征 29
4. 结论 30
致    谢 31
参考文献 32