烷基-(S,Z)-2,4,5-三氨基戊酸盐的合成优化

论文编号:HG064  论文字数:11363,页数:24

摘 要：麦角硫因是自然界中一种稀有天然氨基酸，在机体内具有重要的生理活性，但是不能从在机体内合成，因此只能从饮食中获得。国外研究表明它在生物体内可起抗氧化剂作用并且安全，无毒，是一种理想的天然抗氧化剂。本文以L-组氨酸甲酯二盐酸盐为原料，苯甲酰氯、浓盐酸等作辅料，在四氢呋喃、甲醇等多种溶剂中，合成麦角硫因。采用间歇-多步反应法，逐步制得目标产物麦角硫因。为提高产率，把一个步骤分成两步完成，在每一步后，进行产物的核磁共振谱图和红外光谱图的测定，以此和目标产物进行比对，排除可能发生的副反应，并且在同一条件下进行不同反应温度和浓度的对比试验，调节不适当的反应条件，从而达到对产物合成的优化。

关键词：麦角硫因；抗氧化剂；反应温度；核磁共振和红外光谱图。

Optimization synthetic of alkyl - (S, Z) -2,4,5 - 3 amino valerate
 
Abstract: L-Ergothioneine is a rare natural amino acid, important in vivo biological activity, but cannot synthesize from vivo synthesis, it can only be obtained from the diet. Overseas research shows that it can play an effect and safety role in vivo antioxidant, non-toxic, naturally and ideally. Methyl L-histidinol dihydrochloride as the raw material, benzoyl chloride, concentrated hydrochloric acid for accessories, in tetrahydrofuran, methanol and other solvents, synthesize ergothioneine. this article’s objective is to synthetize ergothioneine, using intermittent - multi-step reaction, and gradually obtained the target product ergothioneine. in order to improve the rate of production ,we separate one step to two steps .After every step ,we determinate the productions with the nuclear magnetic resonance(NMR) spectroscopy and IR spectra with the target production which is prepared in the previous time ,eliminating the side effects which may take place in the reaction. Under the same conditions, different reaction temperature and concentration of contrast test, we adjust the reaction conditions appropriate to achieve the optimization of the synthetic product.

Keywords：L-Ergothioneine; Antioxidant; Chemical reaction temperature; The nuclear magnetic resonance(NMR) spectroscopy and IR spectra.

目  录
中文摘要 I
英文摘要 II
目录 III
1. 绪论 1
 1.1 麦角硫因的概述 1
      1.2 麦角硫应的分布 2
 1.3 麦角硫因的抗氧化性 4
 1.4 麦角硫因的其他生物学功用 6
 1.5 麦角硫因的新陈代谢 6
 1.6 麦角硫因的提取和分离 7
 1.7 麦角硫因的生物化学 8
2. 实验部分 11
 2.1 麦角硫因的化学合成 11
 2.2 实验步骤和现象 12
 3. 结果与讨论 15
 3.1 核磁共振图谱的分析 15
 3.2 红外图谱的分析 17
4．总结与展望 18
致谢 19
参考文献 20