茄尼醇的吸附材料的选取与比较

论文编号:SP134  论文字数:11178,页数:36

摘要：茄尼醇( solanesol) 是一种天然化合物，纯度较高的茄尼醇可以用作多种药物的合成。本文介绍了从烟草中提取茄尼醇，并且对其分离提纯方法作了系统的研究和比较后确定使用柱层析的方法进行分离。运用对照实验研究了茄尼醇柱层析分离最适宜的洗脱剂配比，柱高，上样量等条件并且作出比较选择，确定实验条件。然后将茄尼醇在碱性氧化铝、酸性氧化铝，硅胶，硅镁等吸附剂下进行对照实验，研究其分离效果。研究各种吸附材料得到茄尼醇的纯度以及回收率，得出最佳吸附材料及条件。对照实验的方法用严谨的构思和对比分析取代目前常用的分析方法所需要的复杂的操作、高额的实验成本，并且具有很广泛的适用性，比较高的准确度，可以用作筛选实验条件的主要操作方法。

Abstract: Solanesol (solanesol) is a natural compound, The higher purity Solanesol can be used for the synthesis of a variety of drugs. This paper introduces the extracted from the tobacco Solanesol. Purification and its methods of research and more determined use of column chromatography methods of separation. Experimental study of the use of control Solanesol column chromatography eluting the most appropriate agent ratio, column, on the sample volume conditions and make more choices, to determine experimental conditions. Then Solanesol alumina in alkaline, acidic alumina, silica, silicate magnesia and other adsorbent under control experiments Study their separation. Study adsorption materials to be Solanesol purity and recovery, optimum adsorption materials and conditions. Control experiments using rigorous methods and the idea of replacing the current Comparative Analysis of the analytical method used by the complex needs of the operation, The experimental high costs, and have a broad applicability, the relatively high degree of accuracy. Screening can be used as the main experimental conditions operation.
关键词：茄尼醇；柱层析；吸附材料

Key words: Solanesol; Column chromatography; Adsorption materials

 目  录

中文摘要 ……………………………………………………………………………Ⅰ
外文摘要 ……………………………………………………………………………Ⅱ
目录………………………………………………………………………………Ⅲ
1． 绪论………………………………………………………………………………1
1.1 茄尼醇介绍……………………………………………………………………1
1.2 茄尼醇的作用…………………………………………………………………1
 1.2.1 用于制造一种茄尼醇复合物…………………………………………1
1.2.2 合成辅酶Q10……………………………………………………………1
1.2.3 用于合成N2茄呢基谷氨酰胺类化合物………………………………1
1.2.4 用于合成N-酰基- N’-茄呢基哌嗪衍生物…………………………2
1.2.5 用于合成二元酸茄呢醇乙酰葡萄糖二酯……………………………2
1.3 茄尼醇的市场和经济价值…………………………………………………2
1.4 茄尼醇提取分离方法简介…………………………………………………3
  1.4.1 茄尼醇的分离提取……………………………………………………3
 1.4.2 层析的基本理论………………………………………………………3
 1.4.3 柱层析…………………………………………………………………4
1.4.4 考察已有的紫杉醇提取分离方法……………………………………4
2. 实验部分…………………………………………………………………………5
2.1 实验器材……………………………………………………………………5
 2.2.1 实验步骤………………………………………………………………5
 2.2.2 实验的目的……………………………………………………………6
 2.2.3 实验应该注意的问题…………………………………………………6
3．结果与讨论………………………………………………………………………7
3.1 考察各种条件的改变对吸附效果的影响…………………………………7
4. 总结与展望………………………………………………………………………20
4.1 实验总结……………………………………………………………………20
4.2实验讨论与展望……………………………………………………………20
致谢…………………………………………………………………………………21
参考文献……………………………………………………………………………22