加州大学发现治疗睡眠呼吸暂停同时能够降低血压

　　根据一项最新研究发现，需要持续正压(CPAP)治疗的阻塞性睡眠呼吸暂停(OSA)患者在日间和夜间血压都会出现下降。

　　来自San Diego的California大学(UCSD, CA, USA)研究人员对比了为期两周CPAP和非-CPAP夜间添加氧气治疗患者的24小时动态血压，这些患者患有中度－重度OSA。该项研究总计46例患者年纪在25-65岁之间。3组患者对治疗的依从性相似。

　　2周CPAP治疗引起夜间收缩(6 mm Hg)、平均(5 mm Hg)和舒张(4 mm Hg)血压显著下降。 2周CPAP治疗还导致日间平均和舒张血压显著下降了3 mm Hg。非-CPAP引起夜间收缩血压升高3 mm Hg，夜间吸氧治疗对血压没用显著作用，尽管提高了氧合血红蛋白饱和度。这些研究结果发表在2006年5月的《高血压》之上。
 
　　Sleep Apnea Therapy Also Reduces Blood Pressure
 
　　Both daytime and nighttime blood pressure (BP) are reduced in patients with obstructive sleep apnea (OSA) who use continuous 　positive airway pressure (CPAP) therapy, according to a new study.

　　Researchers from the University of California San Diego (UCSD, CA, USA) compared the effect of two weeks of CPAP versus sham-CPAP versus supplemental nocturnal oxygen on 24-hour ambulatory blood pressure in patients with moderate to severe OSA. A total of 46 patients between the ages of 25 and 65 years were included in the study. The three groups had similar rates of compliance with therapy.

　　Two weeks of CPAP therapy led to significant reductions in nighttime systolic (6 mm Hg), mean (5 mm Hg), and diastolic (4 mm Hg) BP. Two weeks of CPAP therapy also resulted in significant declines of 3 mm Hg in daytime mean and diastolic BP. Sham-CPAP resulted in a 3 mm Hg rise in nighttime systolic BP, while nocturnal supplemental oxygen therapy did not have any significant effect on BP, despite improving oxyhemoglobin saturation. The findings were published in the May 2006 issue of Hypertension.