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资料包括: 论文(5页4758字)
说明:
关键词: 肾脏,基因,发生学
从基因水平来研究器官发生学,将以往的形态发生学的研究方法提高到分子水平。一些基因在肾脏发生,特别是后肾发生中起着重要的作用。当这些基因被破坏时,导致肾脏不能正常地发生,并且对肾脏疾病的形成有着极为深刻的影响。本文对近年来一些基因与肾脏发生的关系,以及这些基因破坏时对肾脏发生影响的有关研究进行综述。
与肾脏发生相关的基因主要在后肾发生阶段发挥作用,它们对后肾的发生起着决定性的作用。这些基因异常可引起后肾的发生、发育障碍。
1 WT-1 基因
WT-1基因是一种肿瘤抑制基因,1990年由Call等克隆,其主要功能是特异识别并结合目标DNA,调节转录。当其识别部位受到影响时,可抑制转录。该基因对泌尿生殖系的发育和儿童wilms肾肿瘤的发生有重要意义。当WT-1基因发生突变时,导致儿童wilms 肾肿瘤。另外芽胚WT-1基因发生突变时与泌尿生殖系的畸型发生有关。WT-1基因最早表达在中肾小管,进一步研究显示,WT-1基因变异体小鼠(mutant mice)中肾小管的头侧与尾侧两个部位发生异常,即中肾小管的尾侧缺乏,头侧在雌性小鼠退化,在雄性小鼠则转为附睾导管[1]。
目录:
1 WT-1 基因
2 Pax-2 基因
3 c-ret 基因
4 GDNF 基因
5 Wnt-4 基因
6 BF-2 基因
7 BMP-7 基因
8 PDGF B基因与PDGF Rβ基因
9 α3β1和α8β1基因
参考文献:
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