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说明：
关键词： 屏障功能,内皮,通透性,调节
摘要 血管内皮屏障功能的调节机制相当复杂。α-凝血酶等炎症性介质引起内皮通透性增高的机制可能是通过G蛋白激活磷脂酶，介导三磷酸肌醇等第二信使产生，并进一步激活蛋白激酶C和肌球蛋白轻链激酶，最终引起球蛋白轻链磷酸化，从而导致内皮细胞F-肌动蛋白骨架重排，中心张力增加，细胞间裂隙形成，内皮细胞通透性发生改变。
Research Progress on Regulation of Vascular endothelial Barrier Function
Abstract The regulatory mechanisms of vascular endothelial barrier function are complicated.Inflammatory mediators,such as-α-thrombin,activate phospholipases to mediate generation of IP3 ans other second messsengers through receptor-coupled G protein.Protein kinase C and myosin light chain kinase are then activated,leading to phosphorylation of myosin light chains,rearrangement of F-actin skeleton,interendothelial cell gap formation and increased endothelial permeability.
Key words Barrier function;Endothelium;Permeablity;Regulation
目录：
一、内皮细胞间连接与内屏障功能
二、基膜对内皮屏障功能的影响
三、内皮屏障功能调节的信号转导
四、内皮通透性增高的逆转和“关闭”（turn off ）
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