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资料包括： 论文(4页3281字)
说明：
关键词： 胰岛素样生长因子,胎儿生长迟缓,胎儿器官成熟
引言
胎儿宫内发育迟缓(IUGR)是指出生体质量小于其孕龄平均体质量的第10百分位者，或者小于其平均体质量的两个标准差者.发病率约为3%～4%.IUGR是围产儿死亡的重要原因之一，新生儿期及远期发病率明显增高.在儿童期比正常儿体格和智力发育均落后.还有研究提示IUGR和成年期发生糖尿病及心血管病有因果联系［1］.鉴于以上原因，IUGR的病因探讨越来越受到人们的重视，尤其是对IUGR内分泌方面的研究也越来越深入.本文着重综述近年来胰岛素样生长因子(insulin-like growth factors,IGFs)与IUGR关系的研究进展情况.
1 IGFs
1957年Salmon发现生长激素(growth hormone,GH)是通过硫酸盐因子介导而间接发挥其硫酸盐活性的.该硫酸盐因子就是后来的IGFs,并从那时起开始了对IGFs的研究.随着对这种生长激素依赖因子的多种代谢作用和不被抗胰岛素抗体阻断的活性的认识，统称为促生长因子(somatomedins).在研究其化学结构的同时，提纯了两种相同的物质，促生长因子A和促生长因子C.由于它们与胰岛素的结构相似被称为胰岛素样生长因子,包括IGF-Ⅰ和IGF-Ⅱ.IGF-Ⅰ与以前的促生长因子A和C是完全相同的［2］.
目录：
1 IGFs
2 IGFs与胎儿生长的关系
3 IGFs与IUGR
4 IGFs对IUGR的诊断和治疗作用
参考文献：
1 Gluckman PD.The endocrine regulation of fetal growth in late gestation:The role of insulin-like growth factors. J Clin Endocrinol Metab, 1995;80(4):1047-1049
2 Ranke MB,Elmlinger M.Functional role of insulin-like growth factor binding proteins. Horm Res, 1997;48(Suppl 4):9-15
3 LeRoith D,Werner H,Beitner-Johnson D.Molecular and cellular aspects of the insulin-like growth factor Ⅰreceptor. Endocr Rev ,1995;16(1):143-163
4 Thiet MP,Osathanondh R,Yeh J.Localization and timing of appearance of insulin,insulin-like growth factor-Ⅰ,and their receptors in the human fetal müllerian tract. Am J Obstet Gynecol,1994;170(1):152-156
5 Baker J,Liu JP,Robertson EJ et al. Role of insulin-like growth factor in embryonic and postnatal growth. Cell,1993;75(1):73-82
6 Kimble R,Harding J,Kolbe A.Intraluminal IGF-Ⅰ ameliorates the histological changes of gut atresia in fetal sheep. International Congress of paediatric Surgery and Paediatric Radiology,Melbourne,1995(abstract)
7 Oliver MH,Harding JE,Breier BH et al.Fetal insulin-like growth factor(IGF)-Ⅰ and IGF-Ⅱ are regulated differently by glucose or insulin-like in the sheep fetus. Reprod Fertil Dev，1993;59(2):167-172
8 Shifren JL,Osathanondh R,Yeh J. Human fetal ovaries and uteri:developmental expression of genes enconding the insulin,insulin-like growth factor-Ⅰ,and insulin-like growth factor Ⅱ receptors. Fertil Steril ,1993;59(4):1036-1040
9 Harding JE,Liu L,Evans PC et al.IGF-Ⅰ alters feto-placental protein and carbohydrate metabolism in fetal sheep. Endocrinology,1994;134:1509-1515
10 Clark R,Strasser J,McCabe S,et al. Insulin-like growth factor-Ⅰ stimulation of lymphopoiesis. J Clin Invest,1993;92(2):504-508
11 Franchimont N,Durant D,Canalis E.Interleukin-6 and its soluble receptor regulate the expression of insulin-like growth factor binding protein-5 in osteoblast cultures. Endocrinology,1997; 138(8):3380-3386
12 Gluckman PD,Harding JE.The physiology and pathophysiology of intrauterine growth retardation. Horm Res,1997;48(Suppl 1):11-16
13 Verhaeghe J,Van Bree R,Van Herck E et al. C-peptide,insulin-like growth factors ⅠandⅡ,insulin-like growth factor binding protein-Ⅰ in umbilical cord serum :correlations with birthweight. Am J Obstet Gynecol,1993;169(1):89-97
14 Owens JA,Kind KL,Carbone F et al. Circulating insulin-like growth factors-Ⅰand -Ⅱ and substrates in fetal sheep following restriction of placental growth. J Endocrinol, 1994,140(1):5-13
15 Crystal RA,Guidice LC.Insulin-like growth factor binding protein profiles in human fetal sera:ontogeny during gestation and differences in newborns with iUGR and LGA newborns. In:Spencer EM,ed. Modern concepts of insulin-like growth factors. New York:Elsevier,1991:395-408
16 Wang HS,Chard T.The role of insulin-like growth factor-Ⅰand insulin-like growth factor-binding protein-Ⅰ in the control of human fetal growth. J endocrinol,1992;132(1):11-19
17 Unterman TG,Simmons RA, Glick RP et al. Circulation leves of insulin,insulin-like growth factor-Ⅰ(IGF-Ⅰ),IGF-Ⅱ,and IGF -binding proteins in the small for gestational age fetal rat. Endocrinology,1993;132(1):327-330
18 Spencer JAD,Chang TC,Jones J et al. Third trimester fetal growth and umbilical venous blood concentrations of IGF-Ⅰ,IGFBP-Ⅰ,and growth hormone at term. Arch Dis Child Fetal Neonatol Ed,1995;73:F87-F90
19 Holmes R,Montemagno R,Jones J et al.Fetal and maternal plasma insulin-like growth factors and binding proteins in pregnancies with appropriate or retarded fetal growth. Early Hum Dev,1997;49(1):7-17
20 Rutanen EM,Pekonen FM, Kinen T et al. Soluble 34k binding protein inhibits the binding of insulin-like growth factor Ⅰ to its cell receptors in human secretory phase endometrium:evidence for autocrine/paracrine regulation of growth factor action. J Clin Endocrinol Metab,1988;66(1):173-180
