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关键词： 一氧化氮,疾病
Inducible nitric oxide synthase in diseases
【A Review】 Nitric oxide(NO) is a biologically active molecule in vivo，it has been found to play an important role not only as a cytotoxic effector but also an immune regulatory mediator and a signal molecule of message transmission．The inducible NO synthase (iNOS) produces NO after cells were activated and play a rather complicated pathophysiological action in a variety of human diseases or disorders. The molecular biological character of iNOS，its expression in human diseases and probable significance were reviewed.
迟至20世纪80年代末，一氧化氮(nitric oxide， NO)才被认识到是人体内一种生物学活性分子。人体内的NO有两个来源。一为非酶生(non-enzymstigenese)，来自体表或者摄入的无机氮的化学降解/转化；一为酶生(enzymstigenese)，由NO合酶(NO synthase NOS)所合成。现已认识到NO既是一个有细胞毒性效应器作用的分子，是组织损伤的诱发因子和各种病变的增强因子，有其病理上不好的一面；又是生物体许多部分的信号(signal)分子，是先天性免疫应答的调节性效应分子，作为一种信息传递物质维持正常的生理功能，有其生理性好的一面。NO的这种双重性在人体的生理和病理过程中起了非常重要的作用［1］。
目录：
一、人iNOS的生物学特征
二、各种疾病中iNOS的表达和意义
三、小结
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