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摘要：目的：探讨微气泡型声学造影剂及二次谐波成像在肝癌中的应用特点。方法：22例肝癌病人经外周静脉注射造影剂前后(剂量0.5～1.0 ml)行基波成像、彩色多普勒成像及二次谐波成像检查。二次谐波成像用1.7/3.4 MHz(ATL-HDI 5000)或1.8/3.6 MHz(HP5500)。结果：肝动脉期肝脏多数无明显增强，少数病灶内出现斑点状回声增强，门静脉增强后肝组织才明显增强，但肿瘤组织增强不明显。增强后有利于低回声病灶的显示而对高回声病灶或中高混杂回声病灶显示无益。增强后可显示更多的瘤血管。彩色多普勒成像增强程度不及二次谐波成像，但结果相似。结论：微气泡型声学造影剂主要反映肝组织总体供血量的变化，相对于正常肝组织来说肝癌总是少血管的。造影剂及谐波成像可以改善血管的显示，谐波成像的组织定征能力有待进一步研究。
关键词： 声学造影剂, 二次谐波成像,肝癌,血管,超声
The initial study of sonographic contrast agent and second harmonic imaging on HCC
Abstract:Purpose: This study is to evaluate microbubble based ultrasonic contrast agent and harmonic imaging on liver tumor.Methods:Before and after media (Dose was from 0.5 to 1.0 ml) were injected into peripheral veins of 22 ptients with hepatocellulor carcinoma (HCC), fundamental imaging、 color Doppler imaging and second harmonic imaging were performed.Second harmonic imaging were performed with ATL-HDI 5000 (1.7/3.4 MHz) or HP5500 (1.8/3.6 MHz). Some cases were just deteced in color Doppler sonography with Logiq500 or AU4(3.5 MHz) after media were injected. Results:Except some spot enhancement on the lesions of five cases,there were little enhancement could be noticed on liver at arterial phase.However,after portal veins were enhanced obviously,the parenchyma of livers were enhanced considerable but not of the tumors.Hypoechoic masses were well detected after administration of contrast agents.Hyperechoic masses and isohyperechoic masses were poorly detected.The media and harmonic imaging increased the echointensity of normal and tumor vessels in liver lesions,there were more vessels could be showed as well. Conclusion:Microbubble based agent is mainly to reflect the blood perfusion of liver in generally. HCC is always hypovascular in relation to the normal liver.Microbubble based agent and harmonic imaging improve the visualization of vessels.It is needed further study to show the tissue characteristics by harmonic imaging.
Key words:contrast agent; second harmonic imaging; liver tumor; blood vessel; ultrasound
目录：
1 资料和方法
2 结果
3 讨论
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