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【摘要】 目的 了解镁与偏头痛发病机制的关系。方法 检测偏头痛发作患者及健康对照组手术后或肿瘤疼痛(疼痛组)患者血清镁和红细胞镁水平，同时给予偏头痛患者静脉注射潘南金(DL-门冬氨酸钾镁)并观察其反应。结果 偏头痛患者较健康对照组及疼痛组血清镁和红细胞镁均明显降低。经潘南金治疗后具有较低血清镁(＜0.76 mmol/L)及红细胞镁(＜1.35 mmol/L)水平的偏头痛患者症状缓解较血清镁(≥0.76 mmol/L)及红细胞镁(≥1.35 mmol/L)水平较高的偏头痛患者缓解明显。结论 血液中镁的浓度对偏头痛发作起着重要作用，并参与发病机制。通过补充镁可缓解偏头痛发作的疼痛。
关键词： 镁,偏头痛,发病机制,治疗,潘南金
A study on magnesium and migraine pathogenesis.
【Abstracts】Objective To understand the role of magnesium in migraine pathogenesis.Methods the levels of total serum magnesium and erythrocyte magnesium in patients with an acute attack of migraine headache ,postoperative or neoplastic pain subjects and normal control subjects were measured. At the same time, the response of patients with migraine headache to an intravenous infusion of Panangin (DL-Potassium magnesium aspratate) was observed. Results Migraine subjects had significantly lower levels of total serum magnesium and erythrocyte magnesium compared with normal control subjects and other pain subjects. After treatment by Panangin, migraine subjects with lower level serum magnesium (＜0.76 mmol/L) and erythrocyte magnesium(＜1.35 mmol/L) had significantly more relief than those with higher levels of serum magnesium(≥0.76 mmol/L) and erythrocyte magnesium (≥1.35 mmol/L).Conclusions Magnesium has the core of reaction in building threshold of migraine attacks and may play a role in pathogenesis of migraine attacks. Pain of migraine can be relieved by the administration of magnesium.
【Key words】 Migraine Magnesium Pathogenesis Treatment Panangin
目录：
1 资料与方法
2 结果
参考文献：
1 Ramadan NM, Halvorson H, Vande-Linde A, et al. Low brain magnesium in migraine. Headache, 1989, 29(7):416
2 Swanson DR. Migraine and magnesium, eleven neglected connections. Perspect Biol Med, 1988, 31(4):526
3 Anonymous. Headche Classification Committee of the Internation Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia, 1988,8(7):10
4 Goldstein S, Zsoter TT. The effect of magnesium on the response of smooth muscle to 5-hydroxytryptamine. Brit J Pharmacol, 1978, 62(5):507
5 Nowak L, Bregestovski P, Ascher P, et al. Magnesium gates glutamate-activated channels in mouse central neurons. Nature, 1984, 307(4):462
6 Foster AC, Fagg GE. Neurobiology. Taking apart NMDA receptor. Nature(London), 1987, 329(3):395
7 Altura BT, Altura BM. Withdrawal of magnesium causes vasospasm while elevated magnesium produces relaxation of tone in cerebral arteries. Neurosci Lett, 1980, 20(3):323
8 Altura BM and Altura BT. Magnesium electrolyte transport and coronary vascular tone. Drugs, 1984, 28(supply):109
9 邵美贞主编.镁的基础与临床.成都：四川科学技术出版社，1996.85
10 Alexander Mauskop, Bella T Altura, Roger Q, et al. Intravenous magnesium sulphate relieves migraine attraine attacks in patients with low serum ionized magnesium levels. Clinical Science, 1995, 89(7):633
11 Gallai V, Sarchielli P, Coata G, et al. Serum and salivary magnesium levels in migraine. Headache, 1992, 32(3):132
