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资料包括： 论文(3页2055字)
说明：
摘要 目的：寻找国人肾移植受者术后早期CsA峰值（C2）的理想治疗窗浓度范围。方法：用特异性荧光偏振免疫法测定58例肾移植受者全血CsA峰值浓度，并按术后不同时间和临床诊断分组比较。结果：肾移植后应用三联免疫抑制治疗中，理想的CsA峰值治疗窗浓度范围为：术后1月内1274.51±271.25ng/ml，术后2月内1328.59±197.25ng/ml，术后3月内1117.05±182.46ng/ml，4月以上964.07±136.52ng/ml。结论：该浓度范围免疫抑制效果满意，排斥反应与药物中毒的发生率相对较少，可作为国人肾移植受者CsA峰值的理想治疗窗浓度范围的参考。
关键词 环孢素A；肾移植；血药浓度监测；治疗窗.
Clinical research of CsA -C2 therapeutic window concentration in renal transplant
recipients
WANG Yiru,LIU Shikun,LIU Yulan，PENG Xiaozhi(The Third Xiangya Hospital of Central
South University,Changsha 410013)
ABSTRACT OBJECTIVE：To search for the proper therapeutic window concentration of CsA in Chinese renal transplant recipients. METHODS: The concentration of CsA 2 hours after its oral administration was determined by FPIA method and analysised by the use of specific monoclone reagent kits. RESULTS:The ideal satisfactory immunosuppressive CsA- C2 was found as follows:The CsA- C2 was 1274.51±271.25ng/ml within the first month after transplantation,1328.59±197.25ng/ml in the second month,1117.05±182.46ng/ml in the third month and within the range of 964.07±136.52ng/ml four months latter. CONCLUSION:The above mentioned range of therapeutic window concentration of CsA- C2 was claimed to be ideal for Chinese renal transplant recipients with no marked toxic effects to the liver and kidney.
KEY WORDS: Cyclosporine A;renal transplantation; therapeutic drug monitoring.
目录：
1 材料与方法
2 结果
3 讨论 环孢素A
