【网学提醒】：本文主要为网上学习者提供纳洛酮治疗Ⅱ型呼吸衰竭肺性脑病的疗效和安全性评价，希望对需要纳洛酮治疗Ⅱ型呼吸衰竭肺性脑病的疗效和安全性评价网友有所帮助，学习一下吧!
资料包括： 论文(4页2675字)
说明：
【摘要】 目的 观察评价纳洛酮治疗Ⅱ型呼吸衰竭肺性脑病临床疗效及安全性。方法 将入选61例病例随机分为治疗组及对照组，两组均予以积极控制感染，持续低流量吸氧(给氧浓度为30%～40%，氧流量为1～3L/min，鼻导管给氧法)，解痉平喘，止咳化痰，保持气道通畅，维持酸碱、水、电解质平衡，营养支持等综合治疗。治疗组在此基础上加用纳洛酮注射剂(0.4mg/支)，首剂负荷量0.8mg加入生理盐水20ml中静脉推注，以后给予纳洛酮注射剂2mg加入生理盐水60ml中，每日2次，用微量泵24h持续静脉泵入，连用3天。结果 治疗后，治疗组总有效率显著高于对照组(P＜0.05)；动脉血气分析指标：动脉血氧分压(PaO2)显著高于对照组(P＜0.05)、动脉血二氧化碳分压(PaCO2)显著低于对照组(P＜0.05)；治疗过程中无不良反应发生。结论 纳洛酮治疗Ⅱ型呼吸衰竭肺性脑病临床疗效确切、安全。
【关键词】 纳洛酮,Ⅱ型呼吸衰竭,肺性脑病,疗效
The observation of the clinical effect and safety of naloxone in treatment of chronic respiratory failure with pulmonary encephalopathy
【Abstract】 Objective To observe the clinical effect and safety of naloxone in treatment of chronic respiratory frailure with pulmonary encephalopathy. Methods 61 patients with chronic respiratory failure with pulmonary encephalopathy were randomly divided into 2 groups,30 cases in the control group were received basic therapy including anti-infection,relieving airway spasm and asthma,etc.31 case in the treating group were given naloxone injection 2mg intravenously by microsyringe twice a day for 3 days. Results After treatment,the total effective rate in the treating group was significantly higher than that in the control group (P＜0.05).PaO2 in the treating group was significantly higher than that in the control group(P＜0.05.PaCO2 in the treating group was significantly lower than that in the control group(P＜0.05).Conclusion Naloxone is an effective and less side-effect medicine for treatment of chronic respiratory failure with pulmonary encephalopathy.
【Key words】 naloxone；respiratory failure；pulmonary encephalopathy；effect
目录：
1 资料与方法
2 结果
3 讨论
参考文献：
1 孟宪芳.纳洛酮在临床急诊中的应用进展.综合临床医学，1997，13(6)：500.
2 中华医学会呼吸病学分会.慢性阻塞性肺病诊治规范.中华结核和呼吸杂志，1997，20(4)：199.
3 崔祥宾，王鸣歧，萨藤三.实用肺脏病学，上海：上海科学技术出版社，1994，588-600.
4 陈天铎，董晨明.纳洛酮对心肺脑复苏作用的评价.急诊医学，2000，9(1)：5-7.
5 季蓉，何权瀛.内源性阿片肽在呼吸调控中的作用.中华结核和呼吸杂志，1999，22(7)：440.
6 徐淑云.临床药理学，上海：上海科学技术出版社，1998，71.
