肺针吸细胞病理学对肺癌早期诊断研究应用
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资料包括： 论文(4页4340字)
说明：
【摘要】 目的 通过肺针吸细胞病理学检验诊断新技术，探讨肺癌早期诊断及鉴别诊断的价值，进而达到早期诊断肺癌的目的。方法 对112例肺部病变（肿块63例，结节41例，实变8例）进行CT引导下经皮肺穿刺细胞病理学诊断，采用22G穿刺针，精选最佳层面进针多部位取材，活检后行瑞-姬双染色，根据细胞学特征及结构特点及组织学检查，个别病例同时做抗酸染色。结果 穿刺成功率99.1%，在112例中，肺恶性肿瘤74例，穿刺敏感性91.1%，特异性76.9%，假阴性8.9%，良性病变37例，均经手术及随访证实。结论 CT引导下经皮肺细针针吸细胞病理学检验诊断具有创伤小、简单快速、安全可靠、准确率高，符合国情、便于推广，为临床肺癌早期诊断提供重要依据。
【关键词】 肺癌,针吸细胞学,早期诊断
Application of cytologic pathology by needle aspiration on early diagnosis of Lung cancer
【Abstract】 Objective Computed tomography (CT) guided fine needle aspiration biopsy (CT guided FNAB) is a new technology of pathological diagnosis. To study new technology of lung cancer diagnosis and differentiation is in early stage, and to achieve the purpose of lung cancer diagnosis and treatment in early stage.Methods Collected 112 specimen of patients（63 specimen of patients were tumor, 41 specimen were tubercle and 8 were solid change） who have lung diseases. Cellular material from these patients by CT-guided FNAB. The aspiration was smeared on glass slides, which were partly air-dried and stained by May-Griinwald and Giemsa, and operate cytological diagnosis and histological diagnosis were made. Specific case examined by acid-fast stain.Results The success rate of CT guided FNAB is 99.1%. And 74 specimen of patients were diagnosed the lung malignant tumour. The puncture sensitivity was 91.1%, speciality rate was 76.9%, and false negative was 8.9%, there were no false positive cases. 37 cases were pathologically benign. All cases were confirmed by surgery and follow-up.Conclusion CT guided FNAB was simple, prompt, safe, dependable and economic, being a safe and moderately invasive diagnostic technique, It is convenient to spread and supplies an important for the carly diagnosis of lung cancer clinically.
【Key words】 lung cancer;cytology of needle aspiration;early diagnosis
目录：
1 材料与方法
2 结果
3 讨论
参考文献：
1 王永才.穿刺脱落细胞诊断学.北京：科学技术文献出版社，1993，36-384.
2 王永才，崔娴维.针吸/脱落细胞诊断学图谱.北京：人民军医出版社，2003，38-76.
3 王永才，张毅.针吸脱落细胞诊断学多媒体图谱.光盘.沈阳：辽宁电子出版社，2004.
4 尤正千，史家云，朱晓平.CT引导下经皮肺穿活检的临床应用（附117例分析）.上海医学影像杂志，2000，11（2）：133-134.
5 Westoott JL， Rao N,Colley DP. Transthorcic needle biopsy of small palmonry nodules. Radiology,1997，202,97.
6 王文辉，田锦标，郭侯林，等.CT引导下经皮肺穿的临床应用价值（附32例报告）.中国临床医学影像杂志，2001，12（2）：98-100.
7 夏诠林，陈渝凤，杨露华，等.70例CT导向肺穿活检的体会.交通影像医学，2000，14（6）：615-616.
8 周晔.CT导引经皮细针肺活检临床应用价值的探讨.浙江中西医结合杂志，1997，7（4）：209-210.
9 Moulton JS， Moore PT.Coaxial percutaneous biopsy technique with automated biopsy devices；walue in improving accuracy and negative predictive. Radiology,1993:186-515.
10 李成洲，张电波，刘士达，等.肺部小结节的CT引导经皮肺穿活检.第二军医大学学报，1999（20）：512.
11 舒仪径，阚秀.细针针吸细胞病理学.北京：人民卫生出版社，2000，512-519.
12 李天潢，黄受方.实用细针针吸细胞学.北京：科学出版社，2000，91-102.
13 马正中，阚秀，刘树范.诊断细胞病理学.郑州：河南科学技术出版社，2000，139-1
60.
资料包括： 论文(4页4340字)
说明：
【摘要】 目的 通过肺针吸细胞病理学检验诊断新技术，探讨肺癌早期诊断及鉴别诊断的价值，进而达到早期诊断肺癌的目的。方法 对112例肺部病变（肿块63例，结节41例，实变8例）进行CT引导下经皮肺穿刺细胞病理学诊断，采用22G穿刺针，精选最佳层面进针多部位取材，活检后行瑞-姬双染色，根据细胞学特征及结构特点及组织学检查，个别病例同时做抗酸染色。结果 穿刺成功率99.1%，在112例中，肺恶性肿瘤74例，穿刺敏感性91.1%，特异性76.9%，假阴性8.9%，良性病变37例，均经手术及随访证实。结论 CT引导下经皮肺细针针吸细胞病理学检验诊断具有创伤小、简单快速、安全可靠、准确率高，符合国情、便于推广，为临床肺癌早期诊断提供重要依据。
【关键词】 肺癌,针吸细胞学,早期诊断
Application of cytologic pathology by needle aspiration on early diagnosis of Lung cancer
【Abstract】 Objective Computed tomography (CT) guided fine needle aspiration biopsy (CT guided FNAB) is a new technology of pathological diagnosis. To study new technology of lung cancer diagnosis and differentiation is in early stage, and to achieve the purpose of lung cancer diagnosis and treatment in early stage.Methods Collected 112 specimen of patients（63 specimen of patients were tumor, 41 specimen were tubercle and 8 were solid change） who have lung diseases. Cellular material from these patients by CT-guided FNAB. The aspiration was smeared on glass slides, which were partly air-dried and stained by May-Griinwald and Giemsa, and operate cytological diagnosis and histological diagnosis were made. Specific case examined by acid-fast stain.Results The success rate of CT guided FNAB is 99.1%. And 74 specimen of patients were diagnosed the lung malignant tumour. The puncture sensitivity was 91.1%, speciality rate was 76.9%, and false negative was 8.9%, there were no false positive cases. 37 cases were pathologically benign. All cases were confirmed by surgery and follow-up.Conclusion CT guided FNAB was simple, prompt, safe, dependable and economic, being a safe and moderately invasive diagnostic technique, It is convenient to spread and supplies an important for the carly diagnosis of lung cancer clinically.
【Key words】 lung cancer;cytology of needle aspiration;early diagnosis
目录：
1 材料与方法
2 结果
3 讨论
参考文献：
1 王永才.穿刺脱落细胞诊断学.北京：科学技术文献出版社，1993，36-384.
2 王永才，崔娴维.针吸/脱落细胞诊断学图谱.北京：人民军医出版社，2003，38-76.
3 王永才，张毅.针吸脱落细胞诊断学多媒体图谱.光盘.沈阳：辽宁电子出版社，2004.
4 尤正千，史家云，朱晓平.CT引导下经皮肺穿活检的临床应用（附117例分析）.上海医学影像杂志，2000，11（2）：133-134.
5 Westoott JL， Rao N,Colley DP. Transthorcic needle biopsy of small palmonry nodules. Radiology,1997，202,97.
6 王文辉，田锦标，郭侯林，等.CT引导下经皮肺穿的临床应用价值（附32例报告）.中国临床医学影像杂志，2001，12（2）：98-100.
7 夏诠林，陈渝凤，杨露华，等.70例CT导向肺穿活检的体会.交通影像医学，2000，14（6）：615-616.
8 周晔.CT导引经皮细针肺活检临床应用价值的探讨.浙江中西医结合杂志，1997，7（4）：209-210.
9 Moulton JS， Moore PT.Coaxial percutaneous biopsy technique with automated biopsy devices；walue in improving accuracy and negative predictive. Radiology,1993:186-515.
10 李成洲，张电波，刘士达，等.肺部小结节的CT引导经皮肺穿活检.第二军医大学学报，1999（20）：512.
11 舒仪径，阚秀.细针针吸细胞病理学.北京：人民卫生出版社，2000，512-519.
12 李天潢，黄受方.实用细针针吸细胞学.北京：科学出版社，2000，91-102.
13 马正中，阚秀，刘树范.诊断细胞病理学.郑州：河南科学技术出版社，2000，139-1
60.